Accessible Navigation. Go to: Navigation Main Content Footer

Lung: Gases & Particles, Asthma, Fibrosis, Cancer

Howard Beall, Ph.D. (Cancer, ROS)

  • Evaluating the role of NQO1 in the bioreductive activation of novel antitumor quinones that are structurally similar to naturally occurring anticancer compounds
  • Testing the potential of aryl isoxazole amides, or AIMs, which interact with a novel molecular target, telomeric G-quadruplex (G4) DNA as malignant glioma anticancer agents;
  • Inflammatory mediators and reactive oxygen and nitrogen species in response to arsenic exposure affecting atherosclerosis and vascular development

Andrij Holian, Ph.D. (Nanotechnology, Lung Fibrosis, Particles, Methamphetamine, Epigenetics and Diet)

  • Characterize mechanisms of particle and nanoparticle uptake by macrophages and the potential role of scavenger receptors in regulating lung inflammation
  • Defining the mechanisms of particle-induced lysosomal disruption leading to NLRP3 inflammasome activation and characteristics of nanoparticles leading to lung pathology
  • Characterize the role of the innate immune response by macrophages contributing to acute and chronic inflammation

Zeina Jaffar, Ph.D. (Lung: Gases & Particles; Systemic Immune)

  • The use of cannabinoid agonists as novel therapeutic agents in suppressing allergic airway inflammation in a mouse model of asthma
  • The role of innate immunity in ozone-induced lung inflammation and asthma exacerbations
  • The role of iNKT cells in the development of allergic lung inflammation

Chris Migliaccio, Ph.D. (Lung: gases & Particles; Epigenetics; Systemic Immune)

  • The effects of inhaled particles on pulmonary immunity and the regulation of inflammatory responses
  • The effects of diet and environmental exposures on immune regulation and pulmonary functions via epigenetic changes
  • Environmental changes to macrophage populations and the subsequent immune dysregulation of inflammatory responses

Curtis Noonan, Ph.D. (Epidemiology, Epigenetics and Diet, Asthma)

  • Impact of in-home interventions on the quality of life and breathing function of asthmatic children living in woodstove homes
  • Collecting data on pregnant women and neonates to investigate the influence/risk of respiratory disease via epigenetic events on gene promoter sites relevant to inflammatory pathways
  • Impact of acute exposures to biomass smoke on cognitive function

Elizabeth Putnam, Ph.D. (Cancer and Genetics, Lung Fibrosis and Particulates, CBPR)

  • Control of protein production related to lung fibrosis and role of the SPARC gene in airway remodeling
  • Pharmacogenomics in underserved and rural populations
  • Gene-environment interactions in the development of asbestos related diseases in Libby, MT

Kevan Roberts, Ph.D. (Lung: Gases & Particles; Systemic Immune)

  • The use of PGI2 and its analogs to regulate allergic airway inflammation in a mouse model of asthma
  • The role of IL-17 producing innate T cells and pentraxin-2 in resolving allergic lung inflammation
  • The use of S-nitroglutathione reductase (GSNOR) inhibitors to limit allergic lung inflammation

Tony Ward, Ph.D. (Exposures, Lung Gases and Particles)

  • Investigate the pulmonary and systemic effects of woodstove smoke exposures on mice and humans
  • Investigate the organic fraction of woodstove smoke to look for new urinary or exhaled breath condensate biomarker candidates
  • Collaborate with Dr. Chris Migliaccio to investigate PM2.5 and coarse PM samples collected in Missoula for mouse/cell studies