Gastrointestinal

Celine Beamer, Ph.D. (Lung and GI Inflammation and Fibrosis, Nanotechnology)

• Role of AhR activation in macrophages and the regulation of NLRP3 inflammasome activation
• Understanding the fate and effects of nanomaterials on the GI tract and determining how CpGs modulate nanomaterials-induced inflammation and immune activation in the lung
• Determine the therapeutic potential of protein cage nanoparticles on the induction of protective immunity in gut and vaginal mucosa

Dave Shepherd, Ph.D. (Systemic Immune, GI, Inflammatory Bowel Disease)

• Role of AhR activation in dendritic cells and the induction of systemic immune suppression
• Role of AhR activation in the gut and consequent regulation of gut inflammation and colitis
• Influence of nanomaterials on gut homeostasis and inflammation
• Therapeutic potential of carbon nanospheres on the induction of protective immunity in gut mucosa