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Celine Beamer, Ph.D. (Lung and GI Inflammation and Fibrosis, Nanotechnology)

  • Role of AhR activation in macrophages and the regulation of NLRP3 inflammasome activation
  • Understanding the fate and effects of nanomaterials on the GI tract and determining how CpGs modulate nanomaterials-induced inflammation and immune activation in the lung
  • Determine the therapeutic potential of protein cage nanoparticles on the induction of protective immunity in gut and vaginal mucosa

Andrij Holian, Ph.D. (Nanotechnology, Lung Fibrosis, Particles, Methamphetamine, Epigenetics and Diet)

  • Characterize mechanisms of particle and nanoparticle uptake by macrophages and the potential role of scavenger receptors in regulating lung inflammation
  • Defining the mechanisms of particle-induced lysosomal disruption leading to NLRP3 inflammasome activation and characteristics of nanoparticles leading to lung pathology
  • Characterize the role of the innate immune response by macrophages contributing to acute and chronic inflammation