Systemic Immune

Zeina Jaffar, Ph.D. (Lung: Gases & Particles; Systemic Immune)

• The use of cannabinoid agonists as novel therapeutic agents in suppressing allergic airway inflammation in a mouse model of asthma
• The role of innate immunity in ozone-induced lung inflammation and asthma exacerbations
• The role of iNKT cells in the development of allergic lung inflammation

Chris Migliaccio, Ph.D. (Lung: gases & Particles; Epigenetics; Systemic Immune)

• The effects of inhaled particles on pulmonary immunity and the regulation of inflammatory responses
• The effects of diet and environmental exposures on immune regulation and pulmonary functions via epigenetic changes
• Environmental changes to macrophage populations and the subsequent immune dysregulation of inflammatory responses

Kevan Roberts, Ph.D. (Lung: Gases & Particles; Systemic Immune)

• The use of PGI2 and its analogs to regulate allergic airway inflammation in a mouse model of asthma
• The role of IL-17 producing innate T cells and pentraxin-2 in resolving allergic lung inflammation
• The use of S-nitroglutathione reductase (GSNOR) inhibitors to limit allergic lung inflammation

Dave Shepherd, Ph.D. (Systemic Immune, GI, Inflammatory Bowel Disease)

• Role of AhR activation in dendritic cells and the induction of systemic immune suppression
• Role of AhR activation in the gut and consequent regulation of gut inflammation and colitis
• Influence of nanomaterials on gut homeostasis and inflammation
• Therapeutic potential of carbon nanospheres on the induction of protective immunity in gut mucosa

Scott Wetzel, Ph.D. (Systemic Immune)

• Impact of the herbicide Atrazine on the activation and differentiation of FoxP3+ CD4+ regulatory T cells
• Effects of Atrazine on antigen presenting cell phenotype and effector functions in the context of inflammation
• Examining the biological consequences of trogocytosis in lymphocyte activation and control of immune responses