Nanotechnology

Celine Beamer, Ph.D. (Lung and GI Inflammation and Fibrosis, Nanotechnology)

• Role of AhR activation in macrophages and the regulation of NLRP3 inflammasome activation
• Understanding the fate and effects of nanomaterials on the GI tract and determining how CpGs modulate nanomaterials-induced inflammation and immune activation in the lung
• Determine the therapeutic potential of protein cage nanoparticles on the induction of protective immunity in gut and vaginal mucosa

Andrij Holian, Ph.D. (Nanotechnology, Lung Fibrosis, Particles, Methamphetamine, Epigenetics and Diet)

• Characterize mechanisms of particle and nanoparticle uptake by macrophages and the potential role of scavenger receptors in regulating lung inflammation
• Defining the mechanisms of particle-induced lysosomal disruption leading to NLRP3 inflammasome activation and characteristics of nanoparticles leading to lung pathology
• Characterize the role of the innate immune response by macrophages contributing to acute and chronic inflammation