Prior education at San Francisco State University (BS & MS) and the University of Montana, Missoula (PhD).
Grant Number: 1 F32 ES019816-01A1 (NRSA)
Project Title: Investigation into Mechanisms NLRP3 Activation by Nickel Associated Multi-Walled Carbon Nanotubes
Sponsoring Agency: NIEHS/NIH
My research goal is to investigate the mechanisms of pulmonary inflammation caused by exposure to inhaled particulates such as engineered nanomaterials (ENM). Because of the industrial usefulness of ENM, it is predicted that the manufacturing of such materials will only increase as a function of time. It is therefore of critical importance to pubic health, that toxicologists be armed with the proper tools to address the health risks associated with these potentially hazardous materials. It is because of, but not limited to, these issues that I am very interested in contributing to the strategies for prevention, and the development of cures for respiratory inflammatory diseases.
Caspase-1 Inhibitors from an Extremophilic Fungus That Target Specific Leukemia Cell Lines. Stierle AA, Stierle DB, Girtsman T. J Nat Prod. 2012 Feb 1.
Caspase-1 and -3 Inhibiting Drimane Sesquiterpenoids from the Extremophilic Fungus Penicillium solitum. Stierle DB, Stierle AA, Girtsman T, McIntyre K, Nichols J. J Nat Prod. 2012 Feb 24;75(2):262-6. Epub 2012 Jan 25.
Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes Stierle DB, Stierle AA, Patacini B, McIntyre K, Girtsman T, Bolstad E. J Nat Prod. 2011 Oct 28;74(10):2273-7
Natural Foxp3+ regulatory T cells inhibit Th2 polarization but are biased towards suppression of Th17-driven lung inflammation. Girtsman T, Jaffar Z, Ferrini M, Shaw P, and Roberts K. (Manuscript in submission to Journal of Leukocyte Biology) 2010. PMCID: PMC2924601.
A Role for Prostacyclin and its Receptor, IP in Regulating Allergic Inflammation and the Humoral Response (Manuscript in preparation) 2010.
Probing for a Hydrophobic a Binding Register in Prostate-Specific Membrane Antigen with Phenylalkylphosphonamidates. Maung J, Mallari, JP, Girtsman TA, Wu LY, Rowley JA, Santiago NM, Brunelle A, Berkman CE, Bioorg. Med. Chem. 2004, 12,4969. PMID: 15336276.
The Role of SV40 in Malignant Mesothelioma and Other Human Malignancies. Pershouse MA, Heivly S, Girtsman T. Inhal Toxicol. 2006 Nov ;18 (12):995-1000. PMID: 16920674.
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